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AstraZeneca and Daiichi Sankyo announced new study results for their cancer drug datopotamab deruxtecan, showing a median survival of 15.6 months in patients with EGFR-mutated non-small cell lung cancer. Agenus plans to cut annual spending by 60% to focus on a late-stage cancer immunotherapy, while Amgen is investing $1 billion to expand its manufacturing in North Carolina. The U.S. Patent and Trademark Office has withdrawn a proposed rule aimed at reducing patent thickets, and Bluebird bio is executing a reverse stock split to comply with Nasdaq rules. Merus received FDA accelerated approval for zenocutuzumab, its first approved product.
Halozyme Therapeutics has made an unsolicited bid to acquire Evotec for 11 euros per share, totaling around 2 billion euros, aiming to enhance its strategic position in the drug industry. Bluebird bio has recorded its first revenue from its gene therapy Lyfgenia for sickle cell disease, while BeiGene has rebranded as BeOne Medicines to emphasize its oncology focus and distance itself from its Chinese roots. Adaptimmune plans to lay off a third of its workforce to save $300 million and focus on its cell therapy Tecelra, while Abeona Therapeutics awaits a decision from the FDA on its gene therapy pz-cel for a rare skin condition by April 2025.
Pfizer has invested $49 million in Triana Biomedicines to develop molecular glue degraders for oncology, while Tim Buckley joins Pfizer's board amid pressure from activist investors. Jazz Pharmaceuticals reported positive Phase 3 results for Zepzelca in small cell lung cancer, prompting plans for expanded FDA approval. MeiraGTx's gene therapy for Parkinson's disease showed safety and encouraging efficacy in a small trial, and Akeso raised $250 million for international trials of its antibody drugs. Inventiva appointed Mark Pruzanski as chairman, securing $100 million for a Phase 3 trial of lanifibranor.
Ben Fidler
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